It is well known that the human body is primarily controlled by the contralateral (opposite side) brain. Hemispheric stroke leaves a vast majority of its sufferers with hemiparesis, rendering the contralesional side of the body non-functional. Recent studies by our group and others have shed some light on the role of ipsilateral (same-side) brain activity in stroke recovery and cortical function in general. The Leuthardt lab is studying this ipsilateral cortical phenomenon in greater detail, with the eventual goal of developing neuroprosthesis for stroke patients. Specifically, our lab is interested in studying the ipsilateral physiology behind upper limb movements in human subjects. We are trying to decode the neural correlates of arm and finger movements in our subjects (epilepsy patients at Barnes-Jewish Hospital under seizure focus monitoring) using electrocorticography (ECoG). It has been speculated that the ipsilateral response during motor movements is primarily inhibitory, but our recent results contradict these speculations. We have shown that these signals are not only a result of transcallosal inhibition, but also have an active component. These activations are also found to have distinct anatomical, spectral and temporal features that are thought to be signatures unique to the ipsilateral cortex. Our group is also interested in investigating the kinematic properties associated with these signals. Arm movements in different spatial directions result in distinct ipsilateral activations, which complement the previous findings of cosine directional tuning found in the contralateral hemisphere. We are attempting to decode these features of cortical response using basic-signal processing and machine-learning techniques.